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Massive ghost theories with a line of defects
Paola Mosconi
Physics , 2003, DOI: 10.1088/0305-4470/36/24/303
Abstract: We study free massive fermionic ghosts, in the presence of an extended line of impurities, relying on the Lagrangian formalism. We propose two distinct defect interactions, respectively, of relevant and marginal nature. The corresponding scattering theories reveal the occurrence of resonances and instabilities in the former case and the presence of poles with imaginary residues in the latter. Correlation functions of the thermal and disorder operators are computed exactly, exploiting the bulk form factors and the matrix elements relative to the defect operator. In the marginal situation, the one-point function of the disorder operator displays a critical exponent continuously varying with the interaction strength.
Open-access clinical trial registries: the Italian scenario
Mosconi Paola,Roberto Anna
Trials , 2012, DOI: 10.1186/1745-6215-13-194
Abstract: Background Citizens, patients and their representatives are increasingly insisting on working with health professionals to organize and discuss research protocols. The International Committee of Medical Journal Editors recommended setting up a public clinical trial registry where anyone can find key information about a trial. Around the world, governments have, in fact, now begun to legislate mandatory disclosure of all clinical trials. The aims of the present survey were to assess the availability of clinical trial registries for Italian citizens and to examine the transparency of the data items reported. Methods The availability of open-access clinical trial registries was surveyed on a sample of 182 websites, including research institutes and centers of excellence (IRCCS-teaching hospitals), hospitals and associations. For each registry we downloaded a sample of two trials to assess the correspondence of the data items reported. Results from the Italian and international registries were compared. Results Fifteen percent of the sample had an open-access registry of clinical trials. Comparison of the data items available, in terms of completeness and transparency, from institutional and international registries indicated wide variability. Conclusions Italian citizens, patients and their associations have scant access to local registries of clinical trials, and international registries are generally more informative. On the European level, advocacy and lobby actions are needed among citizens and patients to boost the diffusion of open-access clinical trial registries without language barriers, thereby facilitating participation, access to information, and the coordination of clinical research.
Patient Organizations’ Funding from Pharmaceutical Companies: Is Disclosure Clear, Complete and Accessible to the Public? An Italian Survey
Cinzia Colombo, Paola Mosconi, Walter Villani, Silvio Garattini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034974
Abstract: Background Many patients’ and consumers’ organizations accept drug industry funding to support their activities. As drug companies and patient groups move closer, disclosure become essential for transparency, and the internet could be a useful means of making sponsorship information accessible to the public. This survey aims to assess the transparency of a large group of Italian patient and consumer groups and a group of pharmaceutical companies, focusing on their websites. Methodology/Principal Findings Patient and consumer groups were selected from those stated to be sponsored by a group of pharmaceutical companies on their websites. The websites were examined using two forms with principal (name of drug companies providing funds, amount of funding) and secondary indicators of transparency (section where sponsors are disclosed, update of sponsorship). Principal indicators were applied independently by two reviewers to the patient and consumer groups’ websites. Discordances were solved by discussion. One hundred fifty-seven Italian patient and consumer groups and 17 drug companies were considered. Thirteen drug companies (76%) named at least one group funded, on their Italian websites. Of these, four (31%) indicated the activities sponsored and two (15%) the amount of funding. Of the 157 patient and consumer groups, 46 (29%) named at least one pharmaceutical company as providing funds. Three (6%) reported the amount of funding, 25 (54%) the activities funded, none the proportion of income derived from drug companies. Among the groups naming pharmaceutical company sponsors, 15 (33%) declared them in a dedicated section, five (11%) on the home page, the others in the financial report or other sections. Conclusions/Significance Disclosure of funds is scarce on Italian patient and consumer groups’ websites. The levels of transparency need to be improved. Disclosure of patient and consumer groups provided with funds is frequent on Italian pharmaceutical companies’ websites, but information are often not complete.
Does a consumer training work? a follow-up survey of the PartecipaSalute training programs
Mosconi Paola,Satolli Roberto,Colombo Cinzia,Villani Walter
Health Research Policy and Systems , 2012, DOI: 10.1186/1478-4505-10-27
Abstract: Background When properly trained through training programs on epidemiology, clinical research and healthcare policy, members of patients’/consumers’ organizations could be helpful for a patient-oriented healthcare system. Since 2006 the not for profit project PartecipaSalute has organized periodic editions of a training program for representatives of citizens’/patients’ organizations. After five editions of this training program, a survey of the long-term satisfaction and the impact on activities has been carried out. Methods A 17-questions follow-up questionnaire has been developed. The sample comprised 99 people who had taken part in at least one program edition. Results The overall response rate was 89% (89 responders/99 participants). About 98% of participants expressed general satisfaction with the training program and with the knowledge gained. Medical and informative topics were rated better than technical ones for their usefulness (96% versus 86%). The results of the survey showed a strong impact of the training course on single participants, while a weak outcome on the activities of the organizations was reported. Conclusions The training program was positively rated, and improvements in personal knowledge were reported. Less impact was reported on organizations’ activities. Participants showed a remarkable willingness to get more involved in healthcare decisions, and to boost their knowledge of health and research issues. The results show the importance of follow-up to understand the real value of training program and to better organize future programs.
Expanded Access Programme: looking for a common definition
Antonella Iudicello,Giulia Benini,Lucia Alberghini,Paola Mosconi
- , 2016, DOI: 10.1186/s13063-015-1108-0
Abstract:
Informing women about hormone replacement therapy: the consensus conference statement
Paola Mosconi, Serena Donati, Cinzia Colombo, Alfonso Mele, Alessandro Liberati, Roberto Satolli, Consensus Conference Working Group
BMC Women's Health , 2009, DOI: 10.1186/1472-6874-9-14
Abstract: We therefore felt that an explicit, rigorous and structured assessment of the information needs on this issue was urgent and we opted for the organisation of a national consensus conference (CC) to assess the current status of the quality of information on hormone replacement therapy (HRT) and re-visit recent research findings on its risks/benefits.We chose a structured approach based on the traditional CC method combined with a structured preparatory work supervised by an organising committee (OC) and a scientific board (SB). The OC and SB chose the members of the CC's jury and appointed three multidisciplinary working groups (MWG) which were asked to review clinical issues and different aspects of the quality of information. Before the CC, the three MWGs carried out: a literature review on the risk/benefit profile of HRT and two surveys on the quality of information on lay press and booklets targeted to women. A population survey on women's knowledge, attitude and practice was also carried out. The jury received the documents in advance, listened the presentations during the two-day meeting of the CCs, met immediately after in a closed-door meeting and prepared the final document. Participants were researchers, clinicians, journalists as well as consumers' representatives.Key messages in the CC's deliberation were: a) women need to be fully informed about the transient nature of menopausal symptoms, about HRT risks and benefits and about the availability of non-pharmacological interventions; b) HRT is not recommended to prevent menopausal symptoms; c) the term "HRT" is misleading and "post menopausal hormone therapy" should be the preferred definition.This CC led to the identification of specific information drawbacks. Women are exposed to messages that are often partial, non evidence-based nor transparently developed. The structured and participative methodology of this CC allowed a multidisciplinary perspective and a substantial lay people input.In Italy, as in
Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study
Federica Andreis, Anna Rizzi, Paola Mosconi, Claudia Braun, Luigina Rota, Fausto Meriggi, Maria Mazzocchi, Alberto Zaniboni
Health and Quality of Life Outcomes , 2010, DOI: 10.1186/1477-7525-8-40
Abstract: Consecutive patients with skin side effects to therapy treated at Fondazione Poliambulanza were enrolled in this study. Quality of life was evaluated with the Italian validated version of Skindex-29 questionnaire, exploring three dimensions: symptoms, emotional, and physical functioning. Skindex-29 was administered one time between the eighth and the twelfth week of the treatment.Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed. Patients showed a great impact of skin side effects on symptoms (mean 43), followed by emotional (mean 30), and functioning (mean 26) scales. In general women, the 55-65 age class, and patients with partial remission reported the worst quality of life.Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales.Epidermal growth factor receptor (EGFR) inhibitors, as cetuximab or panitumumab, have become widely prescribed anticancer drugs for the treatment of colorectal, head and neck and lung cancer, alone or in combination with traditional chemotherapy [1]. Patients treated with EGFR inhibitors commonly develop a wide range of dermatologic adverse drug reactions, including a papulopustular rash, dry skin, itching and alterations in hair and periungual tissues, which can result in a decreased quality of life (QoL) [2]. The rash can occur in 50-90% of patients treated, arising primarily on the face, and appearing similar, but non identical, to acne. The rash can be painful and the paronychial cracking, the paper-cut feeling in the fingers and toes can become very disturbing, and could interfere with the daily activities of a relevant proportion of patients [3]. Moreover many patients experience significant skin side effects and find that these are the
Development and validation of the short version of the Psychological General Well-Being Index (PGWB-S)
Enzo Grossi, Nicola Groth, Paola Mosconi, Renata Cerutti, Fabio Pace, Angelo Compare, Giovanni Apolone
Health and Quality of Life Outcomes , 2006, DOI: 10.1186/1477-7525-4-88
Abstract: Data for this study were collected from 4 different population samples: two general population samples a student and a patient sample. On the basis of the results of the first (development) sample population, six relevant items were identified statistically from the original questionnaire and grouped to assemble a new summary scale. Following the newly created 6-item questionnaire was administered in three independent population samples. Descriptive statistics, correlation coefficients, univariate and multivariate regression analyses were used to compare the performance of the long and short questionnaire, within and between population samples and across relevant subgroups. A further independent sample extracted by an ongoing cancer clinical trial served as final validation step.Overall, the questionnaires were administered to 1443 subjects. Six items were selected by a step-wise approach to explain 90% of the variance of the summary measure of the original questionnaire.Response rates reached 100%, while missing items were not observed. University students (n = 400) showed the highest mean value of the summary measure (75.3); while the patient sample (n = 28) had the lowest score (71.5). The correlation coefficients between the summary measures and the single items according to the different studies were satisfactory, reaching the highest estimates in the student sample. The internal consistency showed high values of the Cronbach's alpha coefficient (range 0.80 – 0.92) for all three study samples, coming close to the value of the coefficient established for the original questionnaire (0.94). A cross-validation in an independent sample of 755 cancer patients confirmed the item selection procedure and amount of variance explained by the new shorter questionnaire (ranging from 90. 2 to 95.1 %, across age and sex strata).The newly identified PGWB-S showed good acceptability and validity for the use in various settings in Italy. The translation of the PGWB-S into differ
Involving a Citizens’ Jury in Decisions on Individual Screening for Prostate Cancer
Cinzia Colombo,Paola Mosconi,Roberto Satolli,Sara Carzaniga,Steering Committee and the Scientific Committee
- , 2016, DOI: 10.1371/journal.pone.0143176
Abstract:
Traducción y evolución de la criminología crítica en la experiencia italiana. Cuestión criminal y derecho penal
Giuseppe Mosconi
Revista de Derecho , 2007,
Abstract: Este escrito reconstruye los aspectos esenciales del modo en el cual la criminología crítica ha sido acogida en la cultura italiana, para focalizar las cuestiones que hoy, ya después de tres decenios de aquel advenimiento, se ponen sobre todo en el terreno de la relación entre saber criminológico y dogmática jurídica.
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